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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

TSH

The determination of serum or plasma levels of thyroid stimulating hormone (TSH or thyrotropin) is recognized as an important measurement in the assessment of thyroid function. Thyroid stimulating hormone is secreted by the anterior lobe of the pituitary gland, and induces the production and release of thyroxine (T4) and triiodothyronine (T3) from the thyroid gland. It is a glycoprotein with a molecular weight of approximately 28,000 daltons, consisting of two chemically different subunits, alpha and beta. Although the concentration of TSH in the blood is extremely low, it is essential in the maintenance of normal thyroid function. The release of TSH is regulated by a TSH-releasing hormone (TRH) produced by the hypothalamus. The levels of TSH and TRH are inversely related to the level of thyroid hormone. When there is a high level of thyroid hormone in the blood, less TRH is released by the hypothalamus, so less TSH is secreted by the pituitary. The opposite action will occur when there are decreased levels of thyroid hormones in the blood. This process, known as a negative feedback mechanism, is responsible for maintaining the proper blood levels of these hormones.

References

  • 1. Marshaal, J.C.: Clinic. In Endocrinol. Metab, 1975, 4:545.
  • 2. Burger, H. G., Patel, Y. C. Thyrotropin releasing hormone-TSH. J. Clinic. Endocrinol. Metab. 1977, 6:831-00.
  • 3. Jeffcoate, S.L.: Clinic. In Endocrinol. Metab. 1975, 4:521.
  • 4. Cohen, K.L.: Metabolism, 1977, 26:1165.
  • 5. Pierce, J. G. Endocrinology. 1971, 89:1331-1344.
  • 6. Berger, S. and Quinn, J.L., Fund. Clin. Chem., N. W. Tietz(ed.), W. B. Saunders Co., Phila., PA 14, 824-848(1976).
  • 7. Lundy, L.E., Lee, S.G., Levy, W., et al. Obstet. Gynecol. 1974, 44:14
  • 8. Utiger, R. D., The Thyroid, S.C. Werner and S. H. Ingbar(eds.), Harper and Row, Hagerstown, MD, 1978, 9:196-205.
  • 9. Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease. Laurence M. Demers, Ph.D., F.A.C.B. and Carole A. Spencer Ph.D.,F.A.C.B., 2002 by the National Academy of Clinical Biochemistry.
  • 10. References intervals for thyroid hormone in pregnant Chinese women, Panesar NS, Li CY and Rogers MS., Ann Clin Biochem 2001;38:329- 32.
  • 11. Interference Testing in Clinical Chemistry; Approved Guideline Second Edition. Robert J. McEroe, PhD, Mary F. Burritt, PhD, Donald M. Powers, PhD, Douglas W. Rheinheimer, MT, Brian H. Wallace, PhD, Clinical and Laboratory Standards Institute.

ichroma™

Compatible Device ichroma™ I/II
Detection Range 0.1~100 uIU/mL
Sample Type Serum, Plasma
CV <10%
Comparability 0.992
Reaction Time 12Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 0.09~80 uIU/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.998
Reaction Time 15Min

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