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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

Cardiac Triple (Tn-I, CK-MB, Myoglobin)

Blood protein markers play an important role in the diagnosis of acute myocardial infarction (AMI) and acute coronary syndrome (ACS). Cardiac troponin-I (Tn-I), creatine kinase (CK-MB), and myoglobin are key members of them. CK–MB levels can be considered as an important diagnostic indicator of myocardial infarction and has been found to be more sensitive and early indicator of myocardial injury. Tn-I is more reliable than creatine kinase as a prognostic marker in people with ischemic chest pain. Myoglobin is a promising cardiac marker when other markers such as CK-MB and Tn-I as well as other indicators like clinical signs and ECG are taken into account for diagnosis/confirmation of AMI..

References

  • 1. Zabel M et al., Analysis of creatine kinase, CK-MB, myoglobin, and troponin T time- activity curves for early assessment of coronary artery reperfusion after intravenous thrombolysis, Circulation, 1993; 87(5): 1542-1550.
  • 2. Apple FS et al., Simultaneous Rapid Measurement of Whole Blood Myoglobin, Creatine Kinase MB, and Cardiac Troponin I by the Triage Cardiac Panel for detection of Myocardial Infarction, Clinical Chemistry, 1999; 45(2): 199–205.
  • 3. Zimmerman J et al., Diagnostic Marker Cooperative Study for the Diagnosis of myocardial Infarction, Circulation, 1999; 99(13): 1671-1677

AFIAS

Compatible Device ichroma™ Ⅱ
Detection Range Tn-I: 0.01-15.00 ng/mL
CK-MB: 3-100 ng/mL
Myoglobin: 5-500 ng/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability Tn-I: 0.9705
CK-MB: 0.9944
Myoglobin: 0.9708
Reaction Time 12 min

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