Rheumatoid arthritis (RA) is the most common chronic autoimmune arthritis worldwide, leading to disability and substantial economic costs. It is a chronic and systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints.
About 1% of the world's population is afflicted by rheumatoid arthritis, women three times more often than men. Onset is most frequent between the ages of 40 and 50, but people of any age can be affected. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated.

References

• 1. Franziska Renge. Immediate determination of ACPA and rheumatoid factor - a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral-flow immunoassay. 2010. Arthritis Res Ther. 12:R120.
• 2. Hiroshi Oka, Shunsei Hirohata. Quantitative determination of IgM-rheumatoid factor by enzyme immunoassay - Standardization using a serum from a rheumatoid arthritis patient. 1990. 188:147-159.
• 3. Williams RC Jr. Autoimmune mechanisms involved in the pathogenesis of rheumatoid arthritis. 1996. Adv Dent Res. 10(1):47-51
• 4. Gioud-Paquet M, Auvinet M, Raffin T, Girard P. IgM rheumatoid factor (RF), IgA RF, IgE RF, and IgG RF detected by ELISA in rheumatoid arthritis. 1987. Ann Rheum Dis. 46(1):65-71.
• 5. Kawashiri SY, Kawakami A, Ueki Y, Imazato T, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Nakamura H, Origuchi T, Ida H, Eguchi K. Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment: comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab. 2010. Joint Bone Spine. 77(5):418-20.

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