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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

PSA

Prostate specific antigen (PSA), a neutral serine protease with chymotrypsin-like activity, is composed of a single polypeptide chain of 237 amino acids. It is an intracellular glycoprotein containing 7-8% carbohydrate as a single N-linked oligosaccharide side chain and has a molecular weight of approximately 34,000 Da. PSA is exclusively synthesized by the prostate epithelium and mainly released into the semen. Normally very small amounts of PSA are secreted and detected in male blood. The elevated levels of PSA in male blood are known to be associated with some prostatic disorders such as prostatitis, benign prostatic hyperplasia (BPH) or prostate cancer.

References

  • 1. Brooks DE, Devine DV, Harris PC, et al. RAMP(TM): A rapid, quantitative whole blood immunochromatographic platform for point-of-care testing. Clin. Chem. 1999; 45:1676-1678.
  • 2. Woolf SH, Rothemich SF. SCREENING FOR PROSTATE CANCER: The Roles of Science, Policy, and Opinion in determining what is best for Patients. Annu. Rev. Med. 1999; 50:207-521.
  • 3. Frankel S, Smith GD, Donovan J, Neal D. Screening for prostate cancer. Lancet 2003; 361:1122-1128.
  • 4. Jung K, Klinggr P, Brux B, et al. Preanalytical Determinants of Total and Free Prostate-Specific Antigen and Their Ratio: Blood Collection and Storage Conditions. Clin. Chem. 1998; 44:685-688

ichroma™

Compatible Device ichroma™ I/II
Detection Range 0.1~100 ng/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.992
Reaction Time 15Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 0.5~100 ng/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.999
Reaction Time 15Min

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