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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

PCT

Identifying sepsis is a daily challenge in intensive care unit of every hospital. Early assessment of sepsis is vital for determination of the appropriate treatment since various therapeutic strategies are known to improve survival of patients with sepsis.
In healthy people, the concentration of plasma PCT is below 0.1 ng/mL. The level of PCT rises rapidly after a bacterial infection with systemic consequences. It can also be elevated by other situation such as major surgery, severe burns, or in neonates. However, it returns to baseline rapidly. Viral infections, bacterial colonization, localized infections, allergic disorders, autoimmune diseases, and transplant rejection do not usually induce a significant PCT response (values <0.5 ng/mL). Therefore, by evaluating PCT concentrations, the physicians are able to engage in the risk assessment for progression to severe sepsis and septic shock.

References

  • 1. Procalcitonin as a Diagnostic Test for Spesis: Health Technology Assessment in the ICU. Gattas and Cook, J Crit Care. 2003, 18:52-8.
  • 2. A new strategy for the development of monoclonal antibodies for the determination of human procalcitonin in serum samples. Kremmer et al, Anal Bioanal Chem. 2012, 402:989-995.
  • 3. Application of procalcitonin (PCT) – Q test for early detection of bacteremia and sepsis. Vetcheva-Dobrevsky et al, R. Vatcheva-Dobrevsky et al, Biotechnol. & Biotechnol. Eq. 2004, 177184
  • 4. Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Meisner et al, Crit Care. 1999, 3:45-50

ichroma™

Compatible Device ichroma™ I/II
Detection Range 0.1~100 ng/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.999
Reaction Time 12Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 0.1~100 ng/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.999
Reaction Time 12Min

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