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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

FSH

Follicle-stimulating hormone (FSH) is synthesized and secreted by gonadotrophs of the anterior pituitary gland. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. FSH has a beta subunit of 118 amino acids (FSHB), which confers its specific biologic action and is responsible for interaction with the FSH-receptor. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the body. FSH and Luteinizing hormone (LH) act synergistically in reproduction. The most common reason for high serum FSH concentration is in a female who is undergoing or has recently undergone menopause. High levels of FSH indicate that the normal restricting feedback from the gonad is absent, leading to an unrestricted pituitary FSH production. If high FSH levels occur during the reproductive years, it is abnormal. Conditions with high FSH levels include: Premature menopause also known as Premature Ovarian Failure, Poor ovarian reserve also known as Premature Ovarian Aging, Gonadal digenesis, Turner syndrome, Castration, Swyer syndrome, Certain forms of Congenital adrenal hyperplasia(CAH), Testicular failure. Most of these conditions are associated with subfertility and/or infertility. Therefore high FSH levels are an indication of subfertility and/or infertility.

References

  • 1. Bruni JF, Van Vugt D, Marshall S, Meites J. Effects of naloxone, morphine and methionine enkephalin on serum prolactin, luteinizing hormone, follicle stimulating hormone, thyroid stimulating hormone and growth hormone. Life Sci. 1977 Aug 1;21(3):461-6.
  • 2. Kim HK, Kee SJ, Seo JY, Yang EM, Chae HJ, Kim CJ. Gonadotropin-releasing Hormone Stimulation Test for Precocious Puberty. Korean J Lab Med. 2011 Oct;31(4):244-9.
  • 3. Reyes FI, Winter JS, Faiman C. Pituitary-ovarian relationships preceding the menopause. I. A cross-sectional study of serum follice-stimulating hormone, luteinizing hormone, prolactin, estradiol, and progesterone levels. Am J Obstet Gynecol. 1977 Nov 1;129(5):557-64.
  • 4. MacNaughton J, Banah M, McCloud P, Hee J, Burger H. Age related changes in follicle stimulating hormone, luteinizing hormone, oestradiol and immunoreactive inhibin in women of reproductive age. Clin Endocrinol (Oxf). 1992 Apr;36(4):339-45.

ichroma™

Compatible Device ichroma™ I/II
Detection Range 1~100 mIU/mL
Sample Type Serum, Plasma
CV <10%
Comparability 0.991
Reaction Time 15Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 1~100 mIU/mL
Sample Type Serum, Plasma
CV <10%
Comparability 0.991
Reaction Time 15Min

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