Colorectal cancer is the third most common cancer in the world[1], with about 1 million new cases and more than 500, 000 deaths per year. Screening method for colorectal cancer include the immuno chromatography fecal occult blood (iFOB) test, barium enema, sigmoidoscopy and colonoscopy[2]. Large randomized controlled trials have shown that iFOB screening can result in decreased colorectal cancer mortality[3,4]. The traditional FOB test uses the chemical Guaiac, which is sensitive to Hb peroxidase activity. However, the Guaiac-FOB test has low sensitivity to clinically significant colorectal neoplasis and has low specificity due to its non-specificity for human Hb[5,6]. To overcome these potential problems in immunochemical test, ichroma™ iFOB Neo uses specific monoclonal antibodies against human Hb. The patient is not forced to avoid food or medicine before the iFOB is tested. ichroma™ iFOB Neo contains a stabilized extraction buffer tube which can be stored in room temperature.
Compatible Device | ichroma™ Ⅱ, ichroma™-50 |
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Detection Range | 25~1,000 ng/mL |
Sample Type | Stool |
CV | <10% |
Performance | LOD: 1.34 ng/mL, LOQ: 25 ng/mL |
Reaction Time | 10 minutes |