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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

Ferritin

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. Ferritin makes iron available for critical cellular processes while protecting lipids, DNA, and proteins from the potentially toxic effects of iron. In clinical medicine, ferritin is predominantly utilized as a marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. It is clear that low ferritin values less than References range are usually representative of body iron deficiency. Recent study suggests that ferritin provides a more sensitive, specific and reliable measurement for determining iron deficiency at an early stage. On other hand, patients with ferritin levels that are higher than the References range may be indicative of conditions such as iron overload, infections, inflammations, collagen diseases, hepatic diseases, neoplastic disease and chronic renal failure.

References

  • 1. Bates HM. How to Detect Iron Deficiency Before Anemia Develops. Laboratory Pathfinder Jan 1980:17-22.
  • 2. Mary Ann Knovich, Jonathan A. Storey, Lan G. Coffman, and Suzy V. Torti, Frank M. Torti. Ferritin for the clinician. Blood Rev. 2009 May ; 23(3): 95–104.
  • 3. Piperno A. Classification and diagnosis of iron overload. Haematologica. 1998;83:447–55.
  • 4. Yutaka Kohgo, Katsuya Ikuta, Takaaki Ohtake, Yoshihiro Torimoto, Junji Kato. Body iron metabolism and pathophysiology of iron overload. Int J Hematol (2008) 88:7–15
  • 5. Lipschitz DA, Cook JD, Finch CA. A Clinical Evaluation of Serum Ferritin as an Index of Iron Stores. N Engl J Med 1974;290:1213-6.
  • 6. Forman DT, Parker SL. The Measurement and Interpretation of Serum Ferritin. Ann Clin Lab Sci 1980;10:345-50.
  • 7. Cook JD, Skikne BS, Lynch SR. Serum Ferritin in the Evaluation of Anemia. In: Albertin A, editor. Radioimmunoassay of Hormones, Proteins and Enzymes. Amsterdam: Excerpta Medica, 1980:239-48.

ichroma™

Compatible Device ichroma™ I/II
Detection Range 10~1,000 ng/mL
Sample Type Serum, Plasma
CV
Comparability 0.99
Reaction Time 10Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 10~1,000 ng/mL
Sample Type Serum, Plasma
CV
Comparability 0.99
Reaction Time 10Min

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