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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

CRP

The C-Reactive Protein (CRP) is synthesized by the liver in response to interleukin-6 and well known as one of the classical acute-phase reactants and as a marker of inflammation. CRP is the first acute-phase protein to be described and is an exquisitely sensitive systemic marker of inflammation and tissue damage. The acute-phase response comprises the nonspecific physiological and biochemical responses of endothermic animals to most forms of tissue damage, infection, inflammation, and malignant neoplasia. The serum CRP level may rise from a normal level of <5 mg/L to 500 mg/L during the body’s general, non-specific response to infectious and other acute inflammatory events. For some time, the measurement of CRP concentration has been used as a clinical tool for monitoring autoimmune diseases and infectious processes, such as rheumatoid arthritis.[1,2]

References

  • 1. Pepys MB and Hirschfield GM. C-reactive protein: a critical update. J Clin. Invest 2003; 111:1805-1812.
  • 2. Volanakis JE. Human C-reactive protein: expression, structure, and function. Mol Immunol 2001;38:189-197. 3. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men. Circulation 1999; 99:237-242.
  • 3. Rifai N, Ridker PM. Proposed Cardiovascular Risk Assessment Algorithm Using High-Sensitivity C-reactive protein and Lipid Screening. Clin. Chem. 2001; 47:28-30
  • 4. Rifai N and Ridker PM. High-Sensitivity C-Reactive Protein: A novel and Promising Marker of Coronary Heart Disease. Clin. Chem. 2001; 47(3): 403-411.

ichroma™

Compatible Device ichroma™ I/II
Detection Range 2.5~300 mg/L
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.988
Reaction Time 3Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 0.5~200 mg/L
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.993
Reaction Time 3Min

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