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TEST ITEMS

THE GENERATION DIAGNOSTIC SYSTEM

βhCG

Human chorionic gonadotropin (hCG) is a glycoprotein hormone secreted by the developing placenta shortly after implantation. It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and β (beta) subunit that is unique to hCG. The β-subunit of hCG gonadotropin (beta-hCG) contains 145 amino acids, encoded by six highly homologous genes that are arranged in tandem and inverted pairs on chromosome 19q13.3. The vast majority of the outer amino acids are hydrophilic. hCG can be detected in the urine and serum of pregnant women as early as 6 to 15 days after conception. The concentration of hCG increases to 50 mIU/ml one week post implantation and reaches to about 100 mIU/ml at the time of the first missed menstrual period and the peak at 100,000-200,000 mIU/ml at the first trimester.

References

  • 1. Braunstein GD, JL Vaitukaitis, PP Carbone, GT Ross “Ectopic production of human chorionic gonadotropin by neoplasms”, Ann. Intern Med. 1973; 78(1): 39-45.
  • 2. Steier JA, P Bergsjo, OL Myking “Human chorionic gonadotropin in maternal plasma after induced abortion, spontaneous abortion and removed ectopic pregnancy”, Obstet. Gynecol. 1984; 64(3): 391-394.
  • 3. Lenton EA, LM Neal, R Sulaiman “Plasma concentration of human chorionic gonadotropin from the time of implantation until the second week of pregnancy”, Fertil. Steril. 1982; 37(6): 773-778.
  • 4. Batzer FR. “Hormonal evaluation of early pregnancy”, Fertil. Steril. 1980; 34(1): 1-13

ichroma™

Compatible Device ichroma™ I/II
Detection Range 5~50,000 mIU/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.989
Reaction Time 15Min

AFIAS

Compatible Device AFIAS-1/6
Detection Range 5~50,000 mIU/mL
Sample Type Whole Blood,
Serum, Plasma
CV <10%
Comparability 0.998
Reaction Time 15Min

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