ASO is an antibody produced in human blood against streptolysin O made from an infection of Streptococcus bacteria. An elevated or rising ASO titer may demonstrate recent streptococcal infections. Some autoimmune responses, glomerulonephritis, acute tonsillitis, scarlet fever and rheumatic fever may be associated with streptococcal infections.
Even if ASO titers may vary due to a number of factors including population and age.

References

• 1. George C. K., Carolyn N. B., Wallis L. K., “Upper limits of normal” Antistreptolsyin O and antideoxyribonuclease B titers. APPL. Microbiol. 1971; 21: 999-1001
• 2. Seckeler M. D., Hoke T. R., The world wide epidemiology of acute rheumatic fever and rheumatic heart disease. Clinical Epidemiology, 2011; 3: 67-84
• 3. Kumar R. K., Tandon R., Rhuematic fever & rheumatic heart disease: The last 50 years. Indian J Med Res. 2013; 137: 643-658
• 4. Claudia S. M. M., Katya O., Alessandra L. B. M., Roberto S. M., Nilton C. M. Antistreptolysin O titer profile in acute rheumatic fever diagnosis, Journal de Pediatr(Rio J) 2001; 77: 105 -111

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